Digoxin Potassium Relationship

I’ve been asked to discuss the relationship between Digoxin levels and potassium…so I will. Digoxin toxicity was discussed earlier this week, and obviously the kidney plays a big role in both digoxin levels and potassium homeostasis. Individuals with low potassium may be more susceptible to possible digoxin toxicity i.e. they may experience toxicity at digoxin levels lower than the usually accepted upper limit of 2–per Lexicomp. What can affect potassium levels? In many cases, digoxin is used in the management of congestive heart failure. In congestive heart failure, there is a high utilization of diuretics (especially loops) which can significantly reduce potassium levels and potentially increase the risk of digoxin toxicity as described above. Close monitoring of renal function and potassium levels are very important in appropriate use of digoxin.


  1. Mitul

    Thank you for a great review!
    so low k increases chance for digoxin toxicity, does digoxin have any effect on potassium levels itself?

  2. Prinz Yusuf

    Thank you so much for this great information.

  3. Khan

    Do we need to supplement potassium prophylactically on low doses with digoxin therapy?

  4. Prof. Dr. Syed Ahmed Hussain

    I would like to congratulate Dr. Eric for helping pharmacist and other health care professionals in improving medication and disease knowledge.
    I am teaching Pharmacotherapy courses in Calgary, Canada. I would like to talk to Dr. Eric on phone if possible.

    • Eric Christianson

      Thanks so much Syed, why don’t you shoot me an email at [email protected] with what you are interested in chatting about? Thanks!

  5. Todd

    Why does low k make dig toxicity more likely at lower levelslevels



  1. DIGOXIN IN CHF – WHAT YOU NEED TO KNOW – JCode Calculator - […] When using digoxin in CHF (more specifically (HFrEF) you must remember to check electrolytes. Alterations in electrolytes may increase…
  2. Antiarrhythmic Comparison Chart - Med Ed 101 - […] is another common antiarrhythmic that is not part of the Vaughan-Williams classification system. Digoxin works by inhibiting the Na/K/ATPase.…

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Written By Eric Christianson

December 15, 2013

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