So you have a patient who has failed a PPI for GERD. Now what? GERD can be a challenging disease with really bothersome symptoms for patients. I’m going to discuss the options that I’ve seen used in practice with once-daily PPI failure in GERD. Before...
Nitroglycerin and its derivatives have been around for a long time. The identification of nitrate tolerance goes back even prior to 1900. In this post, I’ll discuss the major strategy for nitrate tolerance prevention and some of the issues that may be...
Beta-blockers are a class of medication that is frequently used for cardiac and cardiovascular purposes. Selectivity and evidence of benefit often guide selection, but one thing that may get overlooked is beta-blocker interactions in relation to CYP enzymes. Not all...
It is theorized that patients who are taking a GLP-1 agonist are at a greater risk for pancreatitis due to the medication causing an increase in stimulation of GLP-1 receptors located in the pancreas. This could lead to an overgrowth or overactivation of pancreatic...
Bempedoic acid, also known as Nexletol, is a once-daily medication used in patients with increased atherosclerotic cardiovascular disease (ASCVD) or heterozygous familial hypercholesterolemia who are requiring additional LDL-C lowering previously on a maximally...
I don’t recall learning about oxycodone pharmacokinetics in school. Cut me some slack, maybe I was gone that day? Or maybe my memory is fading? It’s actually pretty complicated and drug interactions and pharmacogenomics can play a significant role in how a...
