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Phosphodiesterase-5 inhibitors, or PDE-5 inhibitors, are often the first-line therapy for erectile dysfunction. PDE-5 inhibitors do not produce an erection in the absence of stimulation – rather they enhance the effect of nitric oxide by inhibiting PDE-5-mediated hydrolysis of cGMP, which is present during stimulation. Below we provide a comparison of PDE-5 Inhibitors. Each PDE-5 inhibitor […]
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Last week, the FDA approved finerenone (Kerendia) to treat patients with chronic kidney disease (CKD) associated with type 2 diabetes. Finerenone is a nonsteroidal mineralocorticoid receptor antagonist (MRA). The approval of finerenone was due to the results of the recently completed FIDELIO-DKD trial, which demonstrated the protective effects of finerenone. How does it exhibit these […]
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You’ve likely encountered numerous patients with hyperglycemia. A challenging situation that often comes up in practice is the loss of blood sugar control from a patient who had previously been well controlled. Your first step would be to inquire about adherence. What else should you consider? I always consider looking at possible drugs that cause […]
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Ivermectin and hydroxychloroquine have been purported as potential COVID treatments. We break down where these drugs stand in regards to those claims. The NIH COVID-19 Treatment Guidelines Panel have recommended against any use of chloroquine or hydroxychloroquine (HCQ) for the treatment of COVID-19, including concomitantly with azithromycin. At this point in the pandemic, there has […]
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In this article, we’d like to share some of the most common dextromethorphan clinical pearls that you should be aware of. Dextromethorphan (DXM) is an over-the-counter medication often found in many of the Robitussin products, among others. It is approved to treat cough in adults and children 12 and older. Relief starts 15-30 minutes after […]
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