Celecoxib and Kidney Function – Case Study

A 71 year old female has a past medical history of osteoarthritis, GERD, osteoporosis, hypertension, anxiety, and depression.  Her osteoarthritis has been a chronic problem and she complains of pain all over, but mainly in her hips and knees.  She currently takes an occasional acetaminophen for pain.

Her current medications include:

  • omeprazole 20 mg daily
  • ranitidine 150 mg at bedtime
  • Alendronate 70 mg weekly
  • Calcium 500 mg BID
  • Vitamin D 1,000 units daily
  • Ativan 0.5 mg TID prn
  • Buspirone 5 mg BID
  • Zoloft 100 mg daily
  • Losartan 100 mg daily
  • Hydrochlorothiazide 50 mg daily

Celecoxib 200 mg BID was initiated at her last appointment by her physician.  Her creatinine has now risen from 0.9 to 1.9.  While celecoxib is considered better as far as reducing GI risk compared to traditional NSAIDs, it can definitely impact kidney function in a similar fashion.

What also put this patient at risk was her other medications.  The hydrochlorothiazide as well as the losartan (especially in the presence of COX-2 inhibitors or NSAIDs) both can increase the risk of worsening kidney function.

Alternative medications for osteoarthritis might include trying to maximize the acetaminophen.  Tramadol would be a consideration as well.  Serotonin risk isn’t huge in my mind, but is there with tramadol, so taking it cautious with a small starting dose would be important.  Topical therapy is hard to justify if this patient does have pain all over.  Non-pharmacologic therapies are always an important consideration and should not be overlooked.

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Written By Eric Christianson

August 3, 2016

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