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Here’s a list of some of the most common CYP2C19 drug interactions that I have seen in clinical practice. Citalopram and Omeprazole Interaction Omeprazole can significantly increase the concentration of citalopram. Because of this drug interaction, there is a greater risk for citalopram toxicity and QTc prolongation. Omeprazole inhibits CYP2C19 which is an important breakdown […]
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Here’s a case scenario where the clinical outcome may have hinged on taking ziprasidone with or without food. KD is a 33-year-old male who was diagnosed with schizophrenia. Olanzapine and risperidone were the first antipsychotics that were tried to help alleviate the positive symptoms (hallucinations, delusions, etc.) of schizophrenia. Olanzapine led to a quick uptick […]
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The field of pharmacy is rapidly expanding into areas of specialization. One of those critical areas in pharmacy practice is psychiatry. Becoming a Board Certified Psychiatric Pharmacist can give you an extra edge on jobs in this field as well as help you enhance your clinical pharmacy skillset. Preparation tools for this exam are scarce. […]
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While many who don’t understand pharmacology consider the SSRIs to be interchangeable, significant consequences can result if we don’t pay attention to the risk of drug interactions. When looking at the SSRIs and CYP enzymes, it is critical to remember which ones can interact with other medications. There is also a significant potential that it […]
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At its worst, constipation can be a very serious issue in some patients and at best be a significant nuisance. Here’s a classic example of the constipation prescribing cascade. A 72-year-old female has a history of chronic pain, urinary incontinence, hypertension, and most recently, worsening constipation requiring increasing doses of Senna-S. Her current medication list […]
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