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As I’m working on 2020 updates for all of our board certification study material, I couldn’t help but recognize that I did not have a dedicated lecture on pharmacogenomics. Below I discuss how genetic alterations in CYP2D6 activity can affect two commonly used medications. CYP2D6 is a well known metabolic enzyme that causes structural changes […]
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The SSRI and NSAID interaction kind of drives me crazy. It is one of those interactions where you don’t really know how seriously to take it. SSRI has the potential to impact platelet function. NSAIDs have the potential to impact platelet function. The SSRI and NSAID interaction is represented by an increased risk of bleeding […]
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57 year old patient diagnosed with depression and was initiated on Zoloft (sertraline) 50 mg daily. The physician in this case felt the patient was very depressed, and wanted to titrate the dose up fairly quickly. Zoloft was increased to 100 mg daily after two weeks, and then further to 150 mg two weeks after that. […]
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Weight loss in the younger population generally tends to be less of a problem than weight gain (with the exception of eating disorders etc.). However, in the elderly there are definitely situations where weight loss can be problematic. In these instances we must rule out medications first as there are many medications that can cause […]
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