mirtazapine Archives

Weight Gain With Mirtazapine – The Heavy Truth

Date August 19, 2020 Author By Eric Christianson Category Psych

As previously discussed, mirtazapine can be more sedating at lower doses. Mirtazapine has a high affinity for the H1 (histamine) receptor. This histamine blockade is thought to increase appetite and sedation. Weight gain with mirtazapine can be advantageous or a negative for some patients. One may ask, does weight gain follow a similar dose-dependent effect? […]

Mirtazapine For Insomnia – Are You Using It Correctly?

Date August 9, 2020 Author By Eric Christianson Category Insomnia

Mirtazapine is commonly used in elderly patients with depression who are also suffering from insomnia. Mirtazapine is often chosen because it is much safer than benzodiazepines, “z-drugs”, and antipsychotics. The mechanisms of mirtazapine (podcast episode on the pharmacology) include the release of norepinephrine via presynaptic adrenergic auto-receptor blockade, increased serotonin production through stimulation of adrenoreceptors […]