KE is a 72-year-old female residing in a long-term care facility. She was recently started on ciprofloxacin 500 mg PO BID for a complicated urinary tract infection caused by E. coli. Over the past week, nursing staff noticed she continued to spike fevers, complain of...
Direct oral anticoagulants (DOACs) are widely used in a variety of conditions, including atrial fibrillation, pulmonary embolism, and deep vein thrombosis. Most DOACs are metabolized by CYP3A4 and utilize the P-glycoprotein (P-gp) transporter. Thus, common...
Fluconazole is a commonly used antifungal agent with strong CYP450 inhibitory activity, especially on the CYP2C9, CYP2C19, and CYP3A4 enzymes. Because of this, it can significantly affect the metabolism of many medications. Here are my top five fluconazole drug...
Nonsteroidal anti-inflammatory drugs (NSAIDs) are routinely used for pain and inflammation, but they are also commonly implicated in clinically significant interactions. As medication experts, pharmacists play a critical role in recognizing and navigating these risks....
Rheumatoid arthritis (RA) often requires complex, long-term medication regimens. This polypharmacy increases the risk of clinically significant drug interactions that can impact efficacy and safety. Below are five of the most important drug interactions encountered in...
