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Azole Antifungals Comparison – Indications and Coverage

Azole Antifungals Comparison – Indications and Coverage

by Eric Christianson | May 11, 2025 | Infectious Disease and Oncology Medication and Disease State Clinical Pearls

Azole antifungals play a central role in the treatment and prevention of fungal infections, offering coverage against yeasts, molds, and dimorphic fungi depending on the agent. Each drug in this class comes with its own specific spectrum and set of indications. In a...
Acyclovir Versus Valacyclovir – What’s the Difference?

Acyclovir Versus Valacyclovir – What’s the Difference?

by Eric Christianson | May 7, 2025 | Infectious Disease and Oncology Medication and Disease State Clinical Pearls

When treating herpes simplex virus (HSV) or varicella-zoster virus (VZV), two antiviral agents commonly used are acyclovir and valacyclovir. While both medications are effective, understanding their pharmacokinetic profiles, dosage forms, and clinical uses can help...
Comparing Azole Adverse Effects

Comparing Azole Adverse Effects

by Eric Christianson | Apr 30, 2025 | Infectious Disease and Oncology Medication and Disease State Clinical Pearls

Azole antifungals are known for treating various types of yeast, molds, and dimorphic fungi, however, their safety profiles significantly vary, especially when it comes to hepatotoxicity, QT prolongation, and gastrointestinal (GI) effects. We will break down and...
Prednisone Clinical Pearls – My Top 5

Prednisone Clinical Pearls – My Top 5

by Eric Christianson | Apr 23, 2025 | Hematology and Immunology Medication and Disease State Clinical Pearls

Prednisone is a corticosteroid that I see used almost on a daily basis in my practice. There are many important clinical pearls that will show up in practice as well as on your board exams. In this blog post, I will share my top 5 prednisone clinical pearls....
2025 Benzodiazepine Tapering Guidelines – Top 10 Takeaways

2025 Benzodiazepine Tapering Guidelines – Top 10 Takeaways

by Eric Christianson | Apr 9, 2025 | Psychiatry and Addiction Medication and Disease State Clinical Pearls

Benzodiazepines (BZDs) are FDA-approved for various conditions, such as anxiety, mood disorders, insomnia, and seizures. Although they treat a wide range of conditions, there are many safety concerns including increased risk of falls, cognitive impairment, delirium,...
Sinemet Drug Interactions – Top 5

Sinemet Drug Interactions – Top 5

by Eric Christianson | Apr 2, 2025 | Neurology, Pain, and Musculoskeletal Medication and Disease State Clinical Pearls

Sinemet, a key medication for managing Parkinson’s disease, combines carbidopa and levodopa to improve motor symptoms such as tremors, stiffness, and slow movement. However, Sinemet is known for its potential drug interactions, which can affect its efficacy and lead...
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Recent Posts

  • Why Isn’t Iron Replacement Working? My Top 4 Reasons
  • Can You Identify Two Important Drug Interactions? Case Study
  • A Rundown of Vitamin D Dosing
  • Gabapentin and Metolazone – Prescribing Cascade
  • Desmopressin for Urinary Incontinence – Case Study

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