In the case scenario below, I discuss the implications of the verapamil phenytoin interaction. JS is a 38-year-old male who has been on phenytoin for seizure prophylaxis for several years. He reports to his primary care provider complaining of severe headaches. He is...
In this case scenario below, I discuss the mirabegron tamoxifen interaction and how it can impact patient safety. KS is a 61-year-old female who presents with worsening urinary frequency. She has been diagnosed with overactive bladder and place on oxybutynin. She was...
When the NOACs (sometimes referred to as DOACs) first came out they were heavily promoted as having fewer drug interactions compared to warfarin. This is true, but please remember that “fewer drug interactions” doesn’t mean “no drug...
Lithium has numerous clinical pearls that are essential to remember. Of all the educational points about this medication, you must remember some of these important lithium drug interactions. The list below is not an all-inclusive list, just ones that more commonly...
As I’m working on 2020 updates for all of our board certification study material, I couldn’t help but recognize that I did not have a dedicated lecture on pharmacogenomics. Below I discuss how genetic alterations in CYP2D6 activity can affect two commonly...
Enzyme inducers most frequently reduce the concentrations of other drugs. This can ultimately lead to treatment failure. In rare situations (i.e. prodrugs), starting an enzyme inducer can potentially raise concentrations of the active metabolite and increase the risk...
