by Eric Christianson | Nov 8, 2026 | Renal, Urology, and Electrolytes Case Studies
Chronic kidney disease (CKD) can significantly impact medication clearance and increase the risk of drug toxicity. Three medications I frequently think about in patients with declining renal function are gabapentin, allopurinol, and digoxin. Here are three case...
by Eric Christianson | Jan 11, 2026 | Neurology, Pain, and Musculoskeletal Medication and Disease State Clinical Pearls
In this blog post, I’ll share my top 5 gout pharmacotherapy pearls. This can often show up in practice as well as on those challenging board exams! Allopurinol Doesn’t Treat Flares Allopurinol reduces the production of uric acid. Because of this mechanism,...
by Eric Christianson | Aug 13, 2023 | Cardiovascular Medication and Disease State Clinical Pearls
If you work with patients at all, you’ll see some of the most common antihypertensive agents used on a daily basis. The reason they are used so frequently is because they do not tend to have many significant drug interactions. However, some do exist and I wanted...
by Eric Christianson | Nov 20, 2022 | Pharmacogenomics and Pharmacokinetics Medication and Disease State Clinical Pearls
We’ve been doing some work lately to develop a chart of commonly used drugs with pharmacogenomic considerations. In anticipation of that table, I thought I’d share my top 5 medications that have pharmacogenomic considerations. If you are taking a board...
by Eric Christianson | Oct 12, 2022 | Neurology, Pain, and Musculoskeletal Medication and Disease State Clinical Pearls
Is as needed (PRN) allopurinol appropriate? I have seen as-needed (PRN) orders for allopurinol in practice. It has been rare, but it has happened. Did I like it? No. Allopurinol helps to lower uric acid levels. Allopurinol inhibits xanthine oxidase which is an enzyme...
