Mechanism of Action Questions – Part 2 Fexofenadine What is the primary mechanism of fexofenadine? Blocks H1 receptors Blocks H2 receptors Activates glucocorticoid receptors Blocks leukotriene receptors Fluticasone What is the primary mechanism of fluticasone? Activates glucocorticoid receptors Blocks leukotriene receptors Blocks mineralocorticoid receptors Inhibits prostaglandin synthesis Fosamax What is the mechanism of action of Fosamax? Blocks voltage-gated sodium and calcium channels Inhibit osteoclasts and bone resorption Inhibits xanthine oxidase Antagonizes a1 receptors Furosemide What is the primary mechanism of furosemide? Blocks a1 receptors Blocks mineralocorticoid receptors Blocks sodium reabsorption in the loop of Henle Blocks sodium reabsorption in distal convoluted tubule Gabapentin What is the primary mechanism of gabapentin? Enhances GABA activity Inhibits voltage-gated calcium channels Inhibits voltage-gated sodium channels Inhibits calcium and sodium channels Glipizide What is the primary mechanism of glipizide? Inhibits DPP-4 Reduces hepatic glucose production Stimulates release from beta cells Activates GLP- receptors Guaifenesin What is the primary mechanism of guaifenesin? A2 agonist Increase volume & reduce viscosity of mucus Cough suppressant Nasal decongestant Humalog What is the primary mechanism of Humalog? Rapid-acting insulin analog Short-acting insulin analog Intermediate-acting insulin analog Long-acting insulin analog Hytrin What is the primary mechanism for Hytrin? Blocks A1 receptors Blocks A2 receptors Blocks AT2 receptors & Na+ reabsorption Inhibits angiotensin & neprilysin Imdur What is the primary mechanism of Imdur? Increases nitric oxide Blocks alpha-1 receptors Non-selectively blocks β receptors 5-HT1B/1D receptor agonist Basaglar What is the primary mechanism of Basaglar? Activates GLP-1 receptors, promoting fullness, decreasing appetite, and stimulating insulin release Decreases insulin resistance in the periphery and promotes glucose uptake into muscle Rapid-acting insulin analog Long-acting insulin analog Irbesartan What is the primary mechanism of irbesartan? Blocks angiotensin-II receptors Direct renin inhibitor Inhibits angiotensin-converting enzyme Angiotensin receptor neprilysin inhibitor Januvia What is the primary mechanism of Januvia? Activates GLP-1 receptors Inhibits DPP-4 Inhibits SGLT-2 Inhibits angiotensin & neprilysin Keppra What is the primary mechanism of Keppra? Inhibits Ca2+ channels Inhibits Na+ channels Inhibits Na+ & Ca2+ channels Inhibits Na+/K+ ATPase Lamotrigine What is the primary mechanism of lamotrigine? Inhibit voltage-gated Na+ channels Inhibit ligand-gated Na+ channels Inhibit voltage-gated Ca2+ channels Inhibit ligand-gated Ca2+ channels Lanoxin What is the primary mechanism of Lanoxin? Inhibits H+/K+ ATPase (e.g. omeprazole, lansoprazole, esomeprazole, pantoprazole) Inhibits Na+/K+ ATPase Inhibits voltage-gated calcium channels Inhibits voltage-gated sodium channels Latanoprost What is the primary mechanism of latanoprost? Acetylcholinesterase inhibitor Prostaglandin analog Inhibits prostaglandin synthesis Muscarinic antagonist Lidocaine What is the primary mechanism of lidocaine? Inhibit voltage-gated Na+ channels Inhibit ligand-gated Na+ channels Inhibit voltage-gated Ca2+ channels Inhibit ligand-gated Ca2+ channels Liraglutide What is the primary mechanism of liraglutide? Inhibits DPP-4 Agonizes GLP-1 receptors Inhibit SGLT-2 Stimulate insulin release Lisdexamfetamine What is the primary mechanism of lisdexamfetamine? Increases DA and NE levels Increases NE levels only Blocks 5-HT, DA, and NE reuptake Inhibits NE reuptake Lisinopril What is the primary mechanism of lisinopril? Inhibits angiotensin-converting enzyme Blocks angiotensin receptors Blocks calcium channels Blocks sodium reabsorption in distal convoluted tubule Lopressor What is the primary mechanism of Lopressor? Inhibit angiotensin-converting enzyme Selectively antagonizes β1 receptors Non-selectively antagonizes β receptors Vasopressin analog Lorazepam What is the primary mechanism of lorazepam? GABA-A receptor agonist GABA-A receptor antagonist GABA-B receptor agonist GABA-B receptor antagonist Lopid What is the primary mechanism of Lopid? Dopamine antagonist Osmotic laxative Slow intestinal motility Activates PPAR-ɑ Lovastatin What is the primary mechanism of lovastatin? Inhibits HMG-CoA reductase Inhibits absorption of cholesterol Inhibit ergosterol synthesis Activates PPAR-ɑ Lovenox What is the primary mechanism of Lovenox? Promotes antithrombin activity Direct factor Xa inhibitor Direct thrombin inhibitor Inactivates VKORC1 Name Email Time's up
