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CA is a 58-year-old female with CKD. Her CrCL today is 45 mL/min and stable sCr of 1.3 mg/dL. She complains of muscle aches that started a couple of weeks ago and that her doctor said she can’t use NSAIDs, even though the Tylenol doesn’t completely help the pain. She also reports new mild diarrhea […]
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Statin myopathy is a primary reason why patients stop taking these cholesterol-lowering medications. Here’s a case scenario where I discuss considerations and options to addressing statin myopathy and adverse effect concerns from a patient. SE is a 58-year-old obese male with diabetes and an LDL of 186. The primary provider elected to start atorvastatin 20 […]
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Fibrates are a type of amphipathic carboxylic acid that treat hypertriglyceridemia. They work by reducing the liver’s production of VLDL particles that carry triglycerides to tissues and accelerating the body’s removal of triglycerides. Due to this mechanism of action, they significantly lower triglyceride levels (50-70%), are moderately effective in increasing HDL (5-20%), and do not […]
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As one of the few significant new treatment options approved for reducing the risk of cardiovascular events since statins were approved about 30 years ago, when should icosapent ethyl (Vascepa) actually be used? Icosapent ethyl, sold as Vascepa by Amarin, is a purified form of the ethyl ester of eicosapentaenoic acid (EPA) that was approved […]
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1. The interaction between amlodipine and simvastatin was the first thing I notice – Currently, FDA recommends a max dose of simvastatin 20 mg daily if on Norvasc – Also noted that amlodipine is listed twice which is the generic name of Norvasc. 2. I can’t help but wonder why they are using the methotrexate […]
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