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Enzyme inducers most frequently reduce the concentrations of other drugs. This can ultimately lead to treatment failure. In rare situations (i.e. prodrugs), starting an enzyme inducer can potentially raise concentrations of the active metabolite and increase the risk for toxicity. Throughout my pharmacy career, I’ve been tested on various enzyme inducers. Here’s my top 5. […]
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In the case scenario below, I outline a case where the Bactrim phenytoin interaction leads to phenytoin toxicity. An 81-year-old female has a history of GERD, OA, and seizures. She hasn’t been feeling the best and reports fatigue and painful urination. She has experienced this before and believes she has a urinary tract infection. A […]
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The tacrolimus and azole drug interaction is a concerning one that needs to be monitored. In this case, the drug interaction was actually used to the benefit of the patient. I’m greatly appreciative of this guest post/case from Amanuel Tseggai, PharmD, BCPS! This case involves a 58-year-old African American gentleman with a history of diabetes, […]
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66 year old female was newly diagnosed with atrial fibrillation. Her other diagnoses included hypertension, diabetes, hyperlipidemia, and GERD. Current medication list included: Aspirin 81 mg daily Simvastatin (Zocor) 40 mg at bedtime Tylenol as needed Protonix 40 mg daily Lisinopril 10 mg daily Metformin 500 mg twice daily With the new diagnosis of atrial fibrillation, […]
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Amanuel always goes way above and beyond on his case studies and I can’t say thank you enough to all the guest contributors who’ve shared their stories/cases! It’s folks like him that have made this page what it is today! Please reach out to him if questions or comments at the end of this post. You […]
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